The Guadalupe on Main

At The Guadalupe, modern Mexican flavors meet generations of tradition. Inspired by Jalisco cuisine, Chef Jhomeny Ramos brings a lifetime of experience working alongside his father and brother in the kitchen, with recipes passed down through his family. Named after his grandmother, Guadalupe, our from-scratch menu is rooted in heritage and nearly entirely gluten-free. Paired with an inventive cocktail program and home to 2025 Phoenix New Times “Best Margarita” you’ll be welcomed like family.